Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A.

AG Koesters, MM Rich, KL Engisch - bioRxiv, 2023 - biorxiv.org
… examined whether deletion of Rab3A (Rab3A-/-) might prevent homeostatic upregulation of
… mEPC amplitude was strongly reduced, and was completely abolished in mice expressing a …

Molecular regulation of synaptic release

R Jahn, J Boyken - Neuroscience in the 21st Century: From Basic to …, 2022 - Springer
… processing of neuropeptides, removal of membrane) while … Rab3a, Rab3b, Rab3c, and
Rab27b) involved in docking and … Rupture of this diaphragm leads to the opening of a fusion

[HTML][HTML] Similarity and diversity of presynaptic molecules at neuromuscular junctions and central synapses

K Takikawa, H Nishimune - Biomolecules, 2022 - mdpi.com
… and central synapses: 0.147 μm 2 for rat diaphragm NMJs [23]… knockout mice, the number
of docked synaptic vesicles per … these microdeletions identified common deletions in the ELKS …

Homeostatic plasticity of the mammalian neuromuscular junction

KL Engisch, X Wang, MM Rich - Vertebrate Motoneurons, 2022 - Springer
… of neurotransmitter released via fusion of synaptic vesicles … in mice with a point mutation in
the synaptic vesicle protein … the presynaptic terminal, altering Rab3A function, which triggers …

[HTML][HTML] Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction

JA Szule - Frontiers in Synaptic Neuroscience, 2022 - frontiersin.org
… of certain vesicle trafficking events (ie, docking, priming, Ca 2+ … deletion of Complexin results
in reduced Ca 2+ -triggered … It was concluded that Rab3A is not essential for SV fusion with …

[HTML][HTML] Synaptic secretion and beyond: Targeting synapse and neurotransmitters to treat neurodegenerative diseases

Z Wei, M Wei, X Yang, Y Xu, S Gao, K Ren - Oxidative Medicine and …, 2022 - hindawi.com
reduce the energy barrier to be overcome and ultimately mediate the fusion of synaptic
vesicles and the release … It is formed by the removal of carboxyl group of Glu in the brain under …

Neurotransmitter Release

S Mochida - Physiology of Neurons, 2020 - taylorfrancis.com
… of transmitter release from synaptic vesicles is mediated by … the synaptic vesicular fusion
responsible for transmitter release … As a result, deletion of Munc13 or RIM results, among other …

[HTML][HTML] NMJ-related diseases beyond the congenital myasthenic syndromes

A Navarro-Martínez, C Vicente-García… - Frontiers in Cell and …, 2023 - ncbi.nlm.nih.gov
… Agrin signaling terminates with its removal from the synaptic … of synaptic proteins involved
in neurotransmitter release and … of Rab3A, implicated in calcium-dependent neurotransmitter

Insights into the regulation of podocyte and glomerular function by lactate and its metabolic sensor G‐protein‐coupled receptor 81

K Grochowalska, P Pikul… - Journal of Cellular …, 2022 - Wiley Online Library
… , this study used mice with the deletion of peroxisome … an important role in synaptic signaling.
We hypothesize that … , in which NMDAR blockade and disturbances of Rab3A expression …

[HTML][HTML] miR-142a-3p promotes the proliferation of porcine hemagglutinating encephalomyelitis virus by targeting Rab3a

P Fan, J Guan, W He, X Lv, S Hu, Y Lan, K Zhao… - Archives of …, 2020 - Springer
Rab3a mRNA 3′UTR sequence was amplified from mouse … and Rab3a-WT was greatly
reduced, while mimic- and Rab3a-MUT-… vesicles in the trans-Golgi network, we hypothesize that …